DIAGNOSIS AND TREATMENT
Many parts of India are already reporting cases of Dengue. In this situation, their is only natural remedies to control this dreaded disease.Its Nothing But Carica Papaya Leaves which has been recommended by most of the medical experts(Refernce scroll down).
Papaya Leaves:


If high fever with cold/running nose/nasal block

can be taken twice a day (morning & night)
REFERENCES FOR DENGUE AND CARICA PAPAYA LEAVES
JOURNAL OF THE ASSOCIATION OF PHYSICIANS OF INDIA, JUN’16
A Multi-centric, Double-blind, Placebo-controlled, Randomized, Prospective Study to Evaluate the Efficacy and Safety of Carica papaya Leaf Extract, as Empirical Therapy for Thrombocytopenia associated with Dengue Fever - Prabhu Nagnathappa Kasture, KH Nagabhushan, Arun Kumar
Abstract
Dengue is a rapidly expanding global health problem. Approximately 2.5 billion people live in dengue-risk regions with about 100 million new cases each year worldwide. The cumulative dengue diseases burden has attained an unprecedented proportion in recent times with sharp increase in the size of human population at risk. The management of dengue virus infection is essentially supportive and symptomatic and no specific treatment is available for increasing the fallen platelets, which have a significant role in causing the mortality of dengue patient.This study was conducted to evaluate the platelet increasing efficacy of Carica papaya leaf extract (CPLE) in patients with dengue fever (DF).
AIM
The administration of Carica papaya leaf extract should significantly increase the platelet count in cases of thrombocytopenia associated with dengue, preventing the patient to go in DHF or DSS conditions.
Material and Method
A Multi-centric, Double blind, Placebo controlled, Randomized, prospective study was conducted in 300 patients across 5 centres’, to evaluate the Efficacy and Safety of Carica Papaya Leaf Extract, as empirical therapy for thrombocytopenia associated with dengue fever. The subjects were randomized into two groups, as control and intervention group. Both the groups were managed by the standard management guidelines for dengue except steroid administration. In addition to this, the intervention group received CPLE tablet three times daily for five days. All of them were followed daily with platelet monitoring. This study has been registered in the clinical trial registry–India (CTRI Registration number: CTRI/2015/05/005806)
Results
The results indicate that CPLE had significant increase (p<0.01) in the platelet count over the therapy duration, in dengue fever patients, confirming CPLE accelerates the increase in platelet count compared to the control group. There were few adverse events related to GI disturbance like nausea and vomiting which were similar in both groups.
Conclusion
Thus this study concluded that Carica papaya leaf extract (CPLE) does significantly increase the platelet count in patients with thrombocytopenia associated with dengue with fewer side effects and good tolerability.
INDIAN MEDICAL GAZETTE – DECEMBER 2014
A Pilot Study to Evaluate the Effectiveness of Carica Papaya Leaf Extract in Increasing the Platelet Count in Cases of Dengue with Thrombocytopenia
- A. C. Gowda, Consulting Physician, Poornima Hospital, RT Nagar, Bangalore.
- N. Vijay Kumar, Medical Director and Consulting Physician, S V Hospital, Madiwala, Bangalore.
- P. N. Kasture, Sr. Medical Advisor, Medical Services, K. H. Nagabhushan, Vice President, Medical Services — Micro Labs Ltd., Bangalore.
Abstract
The subjects were randomized into two groups, as control and intervention group. Both the groups were managed by the standard management guidelines for dengue except steroid administration. In addition to this the intervention group received CPLE tablet three times daily for five days. All of them were followed daily with platelet monitoring. The results showed that CPLE had significant increase in the platelet count (p<0.003) over the therapy duration, in dengue fever patients, reiterating that it accelerates the increase in platelet count compared to the control group. There were few adverse events related to GI disturbance like nausea and vomiting which were similar in both groups. Thus this study concluded that Carica papaya leaf extract (CPLE) does significantly increase the platelet count in patients with thrombocytopenia associated fatal, the dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS). The 1997 WHO classification divided dengue into undifferentiated fever, dengue fever (DF), and dengue haemorrhagic fever (DHF)1. Four main characteristic manifestations of dengue illness are (i) continuous high fever lasting 2-7 days; (ii) haemorrhagic tendency as shown by a positive tourniquet test, petechiae or epistaxis; (iii) thrombocytopoenia (platelet count<100x109/1); and (iv) evidence of plasma leakage manifested by haemoconcentration (an increase in haematocrit 20% above average for age, sex and population), pleural effusion and ascites, etc2.
An incubation period varying from 3 to 14 days is followed by a febrile illness consisting of sudden-onset fever, headache, myalgia, arthralgia and rash. Thrombocytopenia is a common feature of the illness6 . The patient develops hemorrhagic manifestations such as petechiae and bleeding through the nose, gastrointestinal tract and gums. After the incubation period, the illness begins abruptly and, in patients with moderate to severe disease, is followed by three phasesfebrile, critical and recovery (Fig. 1). Due to its dynamic nature, the severity of the disease will usually only be apparent around defervescence i.e during the transition of the febrile to the afebrile phase, which often coincides with the onset of the critical phase. (Note- Figure to be taken from the PDF)
IJM – INDONESIA
The effect of Carica papaya L. leaves extract capsules on platelets count and hematocrit level in dengue fever patient - Fenny YUNITA, Endang HANANI, Jusuf KRISTIANTO
Abstract
Indonesia is one of the countries with the highest cases of dengue fever in South East Asia. The number of patient and distribution are increases with increasing mobility and population density. Carica papaya L. (CP) belongs to Caricaceae family is a widely cultivated plant in Indonesia and has many health benefits. The leaves were believed to increase platelet count and dengue fever patient benefit, but there were very limited published reports on scientific evident. The objective of this study was to determine the effects of C. papaya leaves extract capsules (CPC) to dengue fever patient. The design of this study was randomized clinical trial with a sample size of 80 subjects. These subjects were randomized into two group of 40, including the control and intervention group (received two CPC three times daily). The results showed that CPC had significant increased the platelet count (p<0.05), maintained stability of hematocrit in the normal level, shorten hospitalization (p>0.05) in dengue fever patients, and accelerate the increased in platelet count compared with control group.
According to Ministry of Health and Family – India
https://www.nhp.gov.in/disease/musculo-skeletal-bone-joints-/dengue-fever
Carica Papaya is used for Prevention and treatment of dengue and its symptoms
According to National Health Mission – Tamil Nadu
(http://www.nrhmtn.gov.in/vbdc.html)
The State which had reported 13204 cases in 2012 was able to reduce it to 6,122 cases in 2013. During the year 2014 (up to 15.05.2014) 590 Cases are reported with nil death. The Indian medicines such as Papaya juice extract, Nilavembu and Malaivembu kudineer along with conventional medicine are used for the control of Dengue. Daily surveillance is carried out and the disease is now under control.
According to Indian medical Association
(http://www.ima-india.org/ima/left-side-bar.php?scid=383)
- Fresh C. papaya leaf extract significantly increased the platelet and RBC counts in the test group vs controls. (Asian Pac J Trop Biomed. 2013 Sep; 3(9):720-4)
o Carica papaya leaf extract can mediate a Th1 type shift in human immune system. (J Ethnopharmacol. 2010 Feb; 127(3):760-7)
o Plant extracts of Quercus lusitanica have maximum activity against DENV-2 replication of Dengue virus. (Dengue Bull. 2006; 30:260–269)
o C. papaya contains two important biologically active compounds viz. chymopapain and papain. (Biochem Biophys Res Commun. 2006 Mar 10; 341(2):620-6)
o A recent in vitro study demonstrated the possible effectiveness of cocktail extracts prepared from four species of phyllanthus against the DENV. (BMC Complement Altern Med. 2013; 13:192)
o Carica papaya leaves juice significantly increases the platelet count in patients with dengue fever and dengue hemorrhagic fever. (Evid Based Complement Alternat Med. 2013; 2013:616737)
o Thrombocyte count had increased from 28000/micro liter to 138000/micro liter at the end of 5 days. (J Pak Med Assoc. 2014 Mar;64(3):364-6)
o Carica papaya leaves have anti-inflammatory activity. (Inflammopharmacology. 2008 Aug;16(4):168-73)
o C. papaya leaf extract at a dose up to 14 times the levels employed in practical use in traditional medicine in Malaysia could be considered safe as a medicinal agent. (Molecules. 2012 Apr 10; 17(4):4326-42)